Heterocyclic derivatives

Details Heterocyclic derivatives Heterocyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/40 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) C07D 239/38 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2498052

The invention relates to novel heterocyclic derivatives, processes for their preparation, ad their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development. Specifically, the invention relates to compounds of the general formulas (I-A) and (I-B) (see formula I-A) (see formula I-B), wherein A represents an aryl or heteroaryl ring, R1, R2 and R3 independently from each other represent hydrogen, halogen, nitro, cyano, C1-C6-alkyl, hydroxy or C1-C6-alkoxy, R4 represents C1-C6-alkyl, etc., R5 represents C1-C4-alkyl, etc., R6A represents hydrogéna, C1-C6-alkylcarbonyl, C3-C8-cycloalkylcarbonyl, etc., R6B represents C1-C6-alkyl, etc., R7 represents halogen, nitro, cyano, C1-C6-alkyl, hydroxy or C1-C6-alkoxy, and Y1, Y2, Y3 and Y4 independently from each other represent CH or N, wherein the ring contains either 0, 1 or 2 nitrogen atoms.

L'invention concerne de nouveaux dérivés hétérocycliques, des procédés de fabrication de ceux-ci, et leur utilisation dans des médicaments notamment destinés au traitement de maladies pulmonaires obstructives chroniques, du syndrome coronaire aigu, de l'infarctus du myocarde aigu, et de malformations cardiaques.

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