Heterocyclic derivatives

Details Heterocyclic derivatives Heterocyclic derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/52 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 473/00 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2052125

ABSTRACT Compounds of the formula: Image wherein R1 is hydrogen, halogen, nitro, lower alkyl, lower alkoxy, amino or acylamino, R2, R3 and R4 are each hydrogen, halogen, nitro, cyano, lower alkyl, lower alkenyl, lower alkylthio, more or di or trihalo(lower)alkyl, oxo(lower)alkyl, hydroxy(lower)alkyl or optionally esterified carboxy; or R2 and R3 are linked together to form 1,3-butadienylene, R5 is hydrogen or imino-protective group, A is lower alkylene, Q is CH or N, X is N or CH, Y is NH, O or S, and Image is condensed or uncondensed Lmidazolyl which may have suitable substituent(s), and pharmaceutically acceptable salt thexeof. The preparation of these compounds is also described, as well as pharmaceutical compositions containing same, and the treatment of angiotensin II mediated diseases, hypertension and heart failure.

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