Heterocyclic derivatives

Details Heterocyclic derivatives Heterocyclic derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 417/12 (2006.01) A61K 31/435 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2007654

ABSTRACT HETEROCYCLIC DERIVATIVES The invention concerns a triazole of the formula I, Image I wherein Q1 is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents, or Ar is an optionally substituted 6-membered heterocyclene moiety contining up to three nitrogen atoms; R1 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; R2 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl or substituted (1-4C)alkyl or R2 is optionally substituted benzoyl; and Q2 is optionally substituted thiazolyl; or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a thiazole of the formula I and pharmaceutical compositions containing said thiazole.

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