Heterocyclic derivatives and their use as mediators of...

Details Heterocyclic derivatives and their use as mediators of... Heterocyclic derivatives and their use as mediators of...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/501 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2580844

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): Formula (I) where x, y, G, J, L, M, V, W, R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

La présente invention concerne des méthodes de traitement d'une maladie ou d'une pathologie médiée par SCD chez un mammifère, de préférence un homme. Les méthodes consistent à administrer à un mammifère nécessitant un tel traitement, un composé représenté par la formule (I) dans laquelle x, y, G, J, L, M, V, W, R<sp>2</sp>, R<sp>3</sp>, R<sp>4</sp>, R<sp>5</sp>, R<sp>5a</sp>, R<sp>6</sp>, R<sp>6a</sp>, R<sp>7</sp>, R<sp>7a</sp>, R<sp>8</sp> et R<sp>8a</sp> sont tels que définis. Cette invention se rapporte également à des compositions pharmaceutiques comprenant les composés représentés par la formule (I). Formule (I)

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