Heterocyclic derivatives and their use as stearoyl-coa...

Details Heterocyclic derivatives and their use as stearoyl-coa... Heterocyclic derivatives and their use as stearoyl-coa...

C - Chemistry, Metallurgy

07

D

C07D 295/18 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2580856

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, J, K, W, V, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

La présente invention se rapporte à des méthodes permettant de traiter une maladie ou un trouble induits par la SCD chez un mammifère, de préférence un être humain. Les méthodes selon l'invention consistent à administrer à un mammifère concerné un composé représenté par la formule (I), dans laquelle x, y, J, K, W, V, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 et R8a sont tels que définis dans le descriptif de l'invention. L'invention a également trait à des compositions pharmaceutiques contenant les composés représentés par la formule (I).

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