C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01)
Patent
CA 2580762
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where y, G, K, L, M, W, V, R2, R3, R4a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
L'invention concerne des méthodes de traitement d'une maladie ou d'un état pathologique induits par la stéaroyl-CoA désaturase, chez un mammifère, de préférence l'être humain. Les méthodes comprennent l'administration, à un mammifère nécessitant un tel traitement, d'un composé représenté par la formule (I), y, G, K, L, M, W, V, R2, R3, R4a, R6, R6a, R7, R7a, R8 et R8a étant définis dans la demande. Des compositions pharmaceutiques comprenant les composés représentés par la formule (I) sont également décrites.
Bagherzadeh Mehran Seid
Chowdhury Sultan
Fu Jian-Min
Kamboj Rajender K.
Kodumuru Vishnumurthy
Gowling Lafleur Henderson Llp
Xenon Pharmaceuticals Inc.
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