Heterocyclic derivatives and their use as therapeutic agents

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/04 (2006.01)

Patent

CA 2580762

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where y, G, K, L, M, W, V, R2, R3, R4a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

L'invention concerne des méthodes de traitement d'une maladie ou d'un état pathologique induits par la stéaroyl-CoA désaturase, chez un mammifère, de préférence l'être humain. Les méthodes comprennent l'administration, à un mammifère nécessitant un tel traitement, d'un composé représenté par la formule (I), y, G, K, L, M, W, V, R2, R3, R4a, R6, R6a, R7, R7a, R8 et R8a étant définis dans la demande. Des compositions pharmaceutiques comprenant les composés représentés par la formule (I) sont également décrites.

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