Heterocyclic derivatives as inhibitors of factor xa

Details Heterocyclic derivatives as inhibitors of factor xa Heterocyclic derivatives as inhibitors of factor xa

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/395 (2006.01)

Patent

CA 2362392

The invention relates to heterocyclic derivatives, or pharmaceutically- acceptable salts thereof, of formula (I) wherein: A is an optionally substituted 5- or 6-membered monocyclic aromatic ring containing 1, 2 or 3 ring heteroatoms selected from oxygen, nitrogen and sulphur atoms; which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

L'invention concerne des dérivés hétérocycliques, ou des sels pharmaceutiquement acceptables de ceux-ci, de formule (I), dans laquelle A représente un cycle aromatique monocyclique éventuellement substitué à 5 ou 6 chaînons, contenant 1, 2, ou 3 hétéroatomes cycliques choisis parmi les atomes d'oxygène, d'azote, et de soufre. Les dérivés de cette invention possèdent des propriétés antithrombotiques et anticoagulantes et sont donc utiles à des méthodes de traitement d'humains ou d'animaux. Cette invention concerne également des procédés de préparation de ces dérivés hétérocycliques, des compositions pharmaceutiques qui les contiennent, et leur utilisation dans la fabrication de médicaments destinés à produire un effet antithrombotique ou anticoagulant.

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