C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/04 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 31/4192 (2006.01) A61K 31/428 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) A61P 25/00 (2006.01) C07D 333/18 (2006.01) C07D 333/54 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2573819
The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as examplified by compounds of the formula (I) in which Y is independently S, O, or N and m is 1, 2, or 3.
L'invention concerne l'identification de composés appropriés pour l'imagerie de dépôts amyloïdes chez des patients vivants. L'invention concerne, en partie, un procédé d'imagerie de dépôts amyloïdes dans le cerveau in vivo, ce qui permet un diagnostic antemortem de la maladie d'Alzheimer. L'invention concerne enfin des utilisations thérapeutiques de ces composés.
Bacskai Brian
Hills Ivory
Hyman Bradley T.
Klunk William E.
Mathis Chester A.
Massachusetts Institute Of Technology
Smart & Biggar
The General Hospital Corporation
University Of Pittsburgh Of The Commonwealth System Of Higher Ed
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