Heterocyclic ethers

Details Heterocyclic ethers Heterocyclic ethers

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 213/46 (2006.01) A61K 31/435 (2006.01) C07D 213/30 (2006.01) C07D 213/65 (2006.01) C07D 215/14 (2006.01) C07D 215/20 (2006.01) C07D 215/227 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2009900

A B S T R A C T TITLE: HETEROCYCLIC ETHERS The invention concerns a heterocyclic ether of the formula I Image I wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R1 is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl or (2-4C)alkanoyl, or optionally substituted benzoyl; R2 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; and R3 is substituted (1-4C)alkyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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