Heterocyclic hydrazide derivatives of monocyclic beta-lactam...

Details Heterocyclic hydrazide derivatives of monocyclic beta-lactam... Heterocyclic hydrazide derivatives of monocyclic beta-lactam...

C - Chemistry, Metallurgy

07

D

167/211, 167/234

C07D 417/14 (2006.01) A61K 31/425 (2006.01) A61K 31/47 (2006.01) A61K 31/50 (2006.01)

Patent

CA 2024282

GC272 Abstract HETEROCYCLIC HYDRAZIDE DERIVATIVES OF MONOCYCLIC BETA-LACTAM ANTIBIOTICS Antibacterial activity has been found in compounds of the formula Image and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkyl; Q completes a 5- or 6-membered saturated or aromatic heterocyclic ring optionally comprising up to two heteroatoms independently selected from N, NR5, S, O and carbonyl; Y is amino, hydroxy, carboxyl (provided that the heterocyclic ring is not guinoxaline or quinoline), halogen, carboxamide, or nitrile; M? is hydrogen or a cation; and the remaining symbols are as defined in the specification.

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