Heterocyclic indanone potentiators of metabotropic glutamate...

Details Heterocyclic indanone potentiators of metabotropic glutamate... Heterocyclic indanone potentiators of metabotropic glutamate...

A - Human Necessities

61

K

A61K 31/4164 (2006.01) A61K 31/4192 (2006.01) A61K 31/44 (2006.01) C07D 213/70 (2006.01)

Patent

CA 2584598

The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

La présente invention se rapporte à des composés qui sont des potentialisateurs des récepteurs métabotropiques du glutamate, notamment du récepteur mGluR2, et qui sont utiles pour le traitement ou la prévention des troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate et à des maladies dans lesquelles sont impliquées les récepteurs métabotropiques du glutamate. L'invention se rapporte également à des compositions pharmaceutiques comportant ces composés, ainsi qu'à l'utilisation de ces composés et compositions pour la prévention et le traitement des maladies dans lesquelles sont impliquées les récepteurs métabotropiques du glutamate.

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