Heterocyclic inhibitors of erk2 and uses thereof

Details Heterocyclic inhibitors of erk2 and uses thereof Heterocyclic inhibitors of erk2 and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2437767

Described herein are compounds that are useful as protein kinase inhibitors having the formula (I) wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

L'invention concerne des composés de formule (I), utiles en tant qu'inhibiteurs de protéines kinases, où Z?1¿ et Z?2¿ sont chacun indépendamment azote ou CH, et le cycle A, T¿m?mR?1¿, QR?2¿, U¿n?R?3¿, et Sp sont décrits dans la description. Ces composés sont particulièrement utiles en tant qu'inhibiteurs de ERK2 et dans le traitement de maladies chez les mammifères, qui peuvent être soulagées au moyen d'un inhibiteur de protéine kinase, en particulier des maladies telles que le cancer, les troubles inflammatoires, la resténose, les diabètes et les maladies cardio-vasculaires.

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