Heterocyclic inhibitors of glycogen synthase kinase gsk-3

Details Heterocyclic inhibitors of glycogen synthase kinase gsk-3 Heterocyclic inhibitors of glycogen synthase kinase gsk-3

C - Chemistry, Metallurgy

07

D

C07D 285/08 (2006.01) A61K 31/433 (2006.01) A61K 31/4427 (2006.01) A61P 25/28 (2006.01) C07C 49/395 (2006.01) C07C 49/597 (2006.01) C07D 207/44 (2006.01) C07D 207/456 (2006.01) C07D 209/48 (2006.01) C07D 249/12 (2006.01) C07D 277/36 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2408747

Compounds of formula (I) where A, E, G, X, Y, and the bond --- take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is involved, including Alzheimer's disease or the non-dependent insulin diabetes mellitus, or hyperproliferative disease such as cancer, displasias or metaplasias of tissue, psoriasis, arterosclerosis or restenosis.

L'invention concerne des composés représentés par la formule (I) dans laquelle A, E, G, X, Y, et la liaison --- ont des significations variées. Ces composés sont utiles pour la préparation de formulations pharmaceutiques destinées par exemple au traitement d'une maladie dans laquelle la GSK3 est impliquée, notamment la maladie d'Alzheimer ou le diabète non insulino-dépendant, ou les pathologies hyperprolifératives telles que cancers, displasies ou métaplasies tissulaires, psoriasis, artériosclérose ou resténose.

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