Heterocyclic inhibitors of mek and methods of use thereof

Details Heterocyclic inhibitors of mek and methods of use thereof Heterocyclic inhibitors of mek and methods of use thereof

A - Human Necessities

61

K

A61K 31/50 (2006.01) A61K 31/44 (2006.01) A61K 31/519 (2006.01) C07D 221/04 (2006.01) C07D 403/02 (2006.01) C07D 471/02 (2006.01) C07D 487/02 (2006.01)

Patent

CA 2546486

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

L'invention concerne des composés de formule I, ainsi que des sels et des promédicaments pharmaceutiquement acceptables de ces composés. Dans ladite formule, R?1¿, R?2¿, R?7¿, R?8¿ et R?9¿, W, X, Y et Z sont tels que définis dans la description. Ces composés sont des inhibiteurs de MEK et sont utiles dans le traitement des maladies hyperprolifératives, telles que les cancers et les inflammations, et des états inflammatoires, chez des mammifères. L'invention concerne également des méthodes d'utilisation desdits composés dans le traitement des maladies hyperprolifératives chez des mammifères, ainsi que des compositions pharmaceutiques contenant ces composés.

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