Heterocyclic inhibitors of necroptosis

Details Heterocyclic inhibitors of necroptosis Heterocyclic inhibitors of necroptosis

C - Chemistry, Metallurgy

07

D

C07D 285/06 (2006.01) A61K 31/40 (2006.01) A61K 31/433 (2006.01) A61P 25/28 (2006.01) C07D 207/34 (2006.01)

Patent

CA 2696349

The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-.alpha.) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-.alpha. induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.

L'invention concerne une série de dérivés hétérocycliques qui inhibent la nécroptose induite par le facteur a de nécrose tumorale (TNF-a). Les composés hétérocycliques de l'invention sont décrits par les formules (I) et (Ia) à (Ie) et sont connus pour inhiber la nécroptose induite par le TNF-a dans des variantes FADD-déficientes de cellules Jurkat T humaines. L'invention concerne en outre des compositions pharmaceutiques comprenant les composés de l'invention. Les composés et les compositions de l'invention peuvent aussi être utilisés pour traiter des troubles dans lesquels la nécroptose est susceptible de jouer un rôle essentiel.

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