C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/56 (2006.01) A61K 31/44 (2006.01) C07D 213/73 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2331460
The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
La présente invention concerne des inhibiteurs de la protéine p38, une protéine kinase de mammifère intervenant dans la prolifération cellulaire, la mort des cellules et la réponse à des stimuli extracellulaires. L'invention concerne également des procédés de fabrication de ces inhibiteurs, des compositions pharmaceutiques renfermant ces inhibiteurs et des méthodes d'utilisation desdites compositions pour le traitement et la prévention de troubles divers.
Bellon Steven
Bemis Guy
Cochran John
Galullo Vincent
Salituro Francesco
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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