C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/06 (2006.01) C07D 451/04 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2635850
The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
La présente invention concerne un composé de formule (I) doté d~une excellente activité d~inhibition de JAK3 et utile en tant que principe actif d~un médicament destiné à traiter et/ou à prévenir diverses maladies immunitaires, y compris les maladies auto-immunes, les maladies inflammatoires et les maladies allergiques. Le composé selon la présente invention présente une activité d~inhibition vis-à-vis de JAK3 et est à ce titre utile en tant que principe actif d~un médicament destiné à traiter ou à prévenir des maladies induites par la transmission indésirable de signaux de cytokine (p. ex., rejet lors d~une greffe d~organe/de tissu, maladies auto-immunes, sclérose en plaques, polyarthrite rhumatoïde, psoriasis, asthme, dermatite atopique, maladie d~Alzheimer et maladies athéroscléreuses), ou des maladies induites par une transmission anormale de signaux de cytokine (p. ex., cancer et leucémie).
Hamaguchi Hisao
Hatanaka Keiko
Higashi Yasuyuki
Inoue Takayuki
Kunikawa Shigeki
Astellas Pharma Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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