Heterocyclic metalloprotease inhibitors

Details Heterocyclic metalloprotease inhibitors Heterocyclic metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 243/08 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 239/06 (2006.01) C07D 267/10 (2006.01) C07D 281/06 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 487/06 (2006.01)

Patent

CA 2263917

The invention provides compounds of formula (I) as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

Composés présentés dans la formule (I), comme définis dans le descriptif, ou isomère, diastéréomère ou énantiomère optique, sel ou amide, ester ou imide biohydrolysable pharmaceutiquement acceptables de ces composés, utiles comme inhibiteurs de métalloprotéase. Compositions pharmaceutiques et méthodes de traitement de maladies, troubles et états pathologiques caractérisés par l'activité des métalloprotéases avec des composés ou les compositions pharmaceutiques contenant ces derniers.

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