C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/4418 (2006.01) A61K 31/5585 (2006.01) A61P 11/00 (2006.01) C07D 213/75 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2627358
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
La présente invention concerne des composés et des compositions pharmaceutiquement acceptables desdits composés, utiles en tant que modulateurs des transporteurs à cassette liant l~ATP (ATP-binding cassette, « ABC ») ou leurs fragments, y compris le régulateur de la conductance transmembranaire de la fibrose kystique (« CFTR »). La présente invention concerne aussi des méthodes de traitement de maladies dont le médiateur est le transporteur ABC au moyen de composés de la présente invention.
Bear Brian
Grootenhuis Peter D. J.
Hadida Ruah Sara
Hamilton Matthew
Mccartney Jason
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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