C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/48 (2006.01) A61K 31/41 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2692713
The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
L'invention concerne des composés hétérocycliques de la formule I et des compositions de ceux-ci qui s'utilisent pour traiter des maladies induites par la protéine kinase B (PKB), les variables ayant les définitions fournies pour la formule (I). L'invention concerne également l'utilisation thérapeutique de tels composés et des compositions de ceux-ci dans le traitement d'états pathologiques associés à une croissance cellulaire anormale, un cancer, une inflammation et des troubles métaboliques.
Allen John G.
Bourbeau Matthew P.
Dominguez Celia
Falsey James R.
Hong Fang-Tsao
Amgen Inc.
Gowling Lafleur Henderson Llp
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