Heterocyclic oxophthalazinyl acetic acids

Details Heterocyclic oxophthalazinyl acetic acids Heterocyclic oxophthalazinyl acetic acids

C - Chemistry, Metallurgy

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C07D 409/06 (2006.01) A61K 31/50 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1299181

P.C. 7006B HETEROCYCLIC OXOPHTHALAZINYL ACETIC ACIDS Abstract A heterocyclic oxophthalazinyl acetic acid having aldose reductase inhibitory activity of the formula Image I wherein X is oxygen or sulfur, Z is a covalent bond, O, S, NH or CH2 or CHR5Z is vinylene; R1 is hydroxy, or a prodrug group; R2 is a heterocyclic group, R3 and R4 are hydrogen or the same or a different substituent, and R5 is hydrogen, methyl or trifluoromethyl. The pharmaceutically acceptable acid addition salts of the above compounds wherein R1 is di(C1-C4)alkylamino or (C1-C4)alkoxy substituted by N-morpholino or di(C1-C4)alkylamino and the pharmaceutically active base addition salts of the above compounds wherein R1 is hydroxy are also aldose reductase inhibitors.

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