Heterocyclic peptide renin inhibitors

Details Heterocyclic peptide renin inhibitors Heterocyclic peptide renin inhibitors

C - Chemistry, Metallurgy

07

D

167/211, 260/266

C07D 401/14 (2006.01) C07D 211/14 (2006.01) C07D 211/76 (2006.01) C07D 213/74 (2006.01) C07D 233/54 (2006.01) C07D 239/42 (2006.01) C07D 241/04 (2006.01) C07D 241/08 (2006.01) C07D 243/08 (2006.01) C07D 263/10 (2006.01) C07D 263/22 (2006.01) C07D 295/15 (2006.01) C07D 403/06 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2000929

HETEROCYCLIC PEPTIDE RENIN INHIBITORS ABSTRACT OF THE DISCLOSURE A renin inhibiting compound of the formula: Image wherein X is N, O or CH; R1 is absent or a functional group; A and L are independently selected from absent, C=O, SO2 and CH2; D is C=O, SO2 or CH2; Y is N or CH; R2 is hydrogen, loweralkyl or substituted alkyl; Z is a functional group; R3 is loweralkyl or substituted alkyl; n is 0 or 1; and T is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

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