Heterocyclic phenylaminopropanol derivatives as modulators...

Details Heterocyclic phenylaminopropanol derivatives as modulators... Heterocyclic phenylaminopropanol derivatives as modulators...

C - Chemistry, Metallurgy

07

D

C07D 265/36 (2006.01) A61K 31/498 (2006.01) A61K 31/538 (2006.01) A61K 31/5415 (2006.01) A61P 5/24 (2006.01) A61P 15/10 (2006.01) C07D 241/42 (2006.01) C07D 279/16 (2006.01)

Patent

CA 2560966

The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

L'invention concerne des dérivés de phénylaminopropanol représentés par la formule (I) ou un sel de ceux-ci acceptable sur le plan pharmaceutique, des compositions contenant ces dérivés et des procédés d'utilisation de ces dérivés dans la prévention et le traitement de troubles améliorés par la réabsorption de monoamine notamment, entre autres, des symptômes vasomoteurs (VMS), des dysfonctionnements sexuels, des troubles gastro-intestinaux et génito-urinaires, des syndromes de fatigue chronique, des syndromes de fibromyalgie, des troubles du système nerveux, et des combinaisons de ceux-ci, notamment les états choisis dans le groupe constitué de troubles dépressifs majeurs, de symptômes vasomoteurs, d'incontinence par impétuosité et par stress, de fibromyalgie, de douleurs, de neuropathies diabétiques, et de combinaisons de ceux-ci.

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