Heterocyclic protein kinase inhibitors and uses thereof

Details Heterocyclic protein kinase inhibitors and uses thereof Heterocyclic protein kinase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 239/48 (2006.01) C07D 251/18 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2547080

Described herein are compounds that are useful as protein kinase inhibitors of formula (I) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.

L'invention concerne des composés utiles en tant qu'inhibiteurs de protéine kinase représentés par la formule (I) ou un sel pharmaceutiquement acceptable de ces derniers. Dans ladite formule, le noyau B, Z?1¿, Z?2¿, U, p, Q, R?1¿, R?2¿, R?3¿ et R?3¿ sont tels que définis dans le descriptif. Les composés selon l'invention et leurs compositions pharmaceutiquement acceptables conviennent au traitement ou à l'atténuation de la gravité de divers troubles, notamment les accidents vasculaires cérébraux, les troubles inflammatoires, les maladies auto-immunes, telles que le lupus érythémateux disséminé et le psoriasis, les troubles prolifératifs, tels que le cancer et les états pathologiques associés à la transplantation d'organes.

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