Heterocyclic side chain containing metalloprotease inhibitors

Details Heterocyclic side chain containing metalloprotease inhibitors Heterocyclic side chain containing metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/34 (2006.01) A61K 31/4545 (2006.01) A61P 29/00 (2006.01) C07D 211/66 (2006.01) C07D 309/06 (2006.01) C07D 335/02 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2404076

Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I) where R1, R2, n, A, E, X, G and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.

L'invention concerne des composés qui sont des inhibiteurs de métalloprotéases et qui sont efficaces au niveau du traitement d'états se caractérisant par une activité excessive de ces enzymes. En particulier, ces composés présentent une structure correspondant à la Formule (I). La signification de R?1¿, R?2¿, n, A, E, X, G et Z est donnée dans le descriptif et les revendications, ainsi que celle des isomères optiques, diastéréomères et énantiomères de la Formule (I) et de leurs sels, amides biohydrolysables, esters et imides pharmaceutiquement acceptables y relatifs. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, ainsi que des procédés destinés à traiter, à l'aide de ces composés ou compositions pharmaceutiques, des maladies se rapportant aux métalloprotéases.

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