C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/34 (2006.01) A61K 31/35 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 211/66 (2006.01) C07D 211/96 (2006.01) C07D 309/06 (2006.01) C07D 309/08 (2006.01) C07D 309/14 (2006.01) C07D 401/12 (2006.01) C07D 407/12 (2006.01)
Patent
CA 2404131
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I): where R1, R2, R3, n, A, E, X, G, G', M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
L'invention concerne des composés, en l'occurrence des inhibiteurs des métalloprotéases, qui sont efficaces pour le traitement des états caractérisés par une suractivité de ces enzymes. L'invention concerne notamment des composés dont la structure est représentée par la formule (I): où R?1¿, R?2¿, R?3¿, n, A, E, X, G, G', M et Z ont la signification qu'en donnent la description et les revendications. L'invention concerne également des isomères, diastéréomères et énantiomères optiques de formule (I), ainsi que leurs sels, et leurs amides, esters et imides biohydrolysables acceptables au plan pharmaceutique. L'invention porte, en outre, sur des compositions pharmaceutiques contenant lesdits composés, et sur des méthodes de traitement des maladies associées aux métalloprotéases faisant intervenir les composés ou les compositions pharmaceutiques de l'invention.
Almstead Neil Gregory
De Biswanath
Laughlin Steven Karl
Natchus Michael George
Ohler Norman Eugene
Ledgley Law
The Procter & Gamble Company
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