C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01) A01N 43/04 (2006.01) A01N 43/34 (2006.01) A61K 31/58 (2006.01)
Patent
CA 2077680
2077680 9113903 PCTABS00007 The present invention relates to novel substituted 15-oxa-, 15-thia-, and 15-aza-dihydrolanosterols, to pharmaceutical compositions containing such compounds, and to methods of using these compounds to suppress the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), an enzyme which is important in cholesterol biosynthesis. The overall effect of these heterocyclic lanosterol analogs is to decrease cholesterol formation, thereby resulting in lower serum cholesterol levels in mammals, and impaired ergosterol synthesis in fungi.
Ko Soo S.
Trzaskos James M.
Du Pont Merck Pharmaceutical Company
Sim & Mcburney
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