Heterocyclic substituted piperazinone derivatives as...

Details Heterocyclic substituted piperazinone derivatives as... Heterocyclic substituted piperazinone derivatives as...

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/405 (2006.01) A61K 31/495 (2006.01) C07D 209/20 (2006.01) C07D 209/26 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2215333

The present invention relates to substituted piperazinone derivatives of formula (1), stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).

La présente invention se rapporte à des dérivés de pipérazinone substitués de la formule (1), à leurs stéréoisomères ou leurs sels pharmaceutiquement acceptables, ainsi qu'à leur utilisation comme antagonistes du récepteur de tachykinine. De tels antagonistes peuvent être utilisés pour le traitement des maladies et des états induits par tachykinine décrits dans le cadre de cette invention, y compris l'asthme, la toux et la bronchite. La présente invention concerne également des intermédiaires pouvant être utilisés dans la préparation des composés de la formule (1).

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