Heterocyclic substituted piperidines and uses thereof

Details Heterocyclic substituted piperidines and uses thereof Heterocyclic substituted piperidines and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 263/20 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 277/14 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 411/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2294549

This invention is directed to oxazolidinone compounds which are selective antagonists for human .alpha.1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the .alpha.1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Cette invention concerne des composés d'oxazolidinone qui sont des antagonistes sélectifs des récepteurs .alpha.¿1A? humains. Cette invention concerne également les différentes utilisations de ces composés pour réduire la pression intra-oculaire, empêcher la synthèse du cholestérol, détendre les tissues du tractus urinaire inférieur, traiter l'hyperplasie prostatique bénigne, l'impuissance, l'arythmie cardiaque et pour traiter toute maladie dans laquelle l'antagoniste du récepteur .alpha.¿1A? peut être utile. Cette invention concerne également une composition pharmaceutique contenant une quantité thérapeutiquement efficace des composés présentés ci-avant ainsi qu'un support pharmaceutiquement acceptable.

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