Heterocyclic sulfonamide derivatives as antagonists of paf...

Details Heterocyclic sulfonamide derivatives as antagonists of paf... Heterocyclic sulfonamide derivatives as antagonists of paf...

C - Chemistry, Metallurgy

07

D

C07D 233/61 (2006.01) A61K 31/395 (2006.01) C07C 311/17 (2006.01) C07D 215/36 (2006.01) C07D 233/54 (2006.01) C07D 233/68 (2006.01) C07D 233/91 (2006.01) C07D 239/36 (2006.01) C07D 239/80 (2006.01) C07D 249/08 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 473/40 (2006.01) C07D 487/04 (2006.01) C07D 495/04 (2006.01) C07D 521/00 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2127367

2127367 9314069 PCTABS00024 Compounds of formula (I), wherein: A represents: a) a -VR6 group wherein v is -C(=O)-, -C(=O)O-, -CH2O-, -CH2OC(=O)-, -C(=S)-, -CH2OC(=O)NH-, -C(=S)O-, -CH2S-, -C(=O)NHSO2-, -SO2NHC(=O)- or -CH2OSiPh2-; b) a -CH2NR9R10 group or a -CONR9R10 group wherein each of R9 and R10 is independently hydrogen, -alkyl-, -alkenyl-, -alkynyl, -cycloalkyl, -cycloalkenyl, pyridyl (any of which may optionally be substituted) or a group -D as defined above or R9 and R10 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring; c) a group Y where Y is a 5- or 6-membered optionally substituted heterocyclic ring containing one or more heteroatoms selected from nitrogen, oxygen and sulphur; or d) a group -CH2-Y or -C(=O)NHY; where Y is as defined above; B represents: a 5- or 6-membered heterocyclic ring containing one or more nitrogen atoms in its ring, are antagonists of platelet activating factor (PAF) and/or antagonists of angiotensin II.

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