Heterocyclic sulfonamide inhibitors of beta amyloid production

Details Heterocyclic sulfonamide inhibitors of beta amyloid production Heterocyclic sulfonamide inhibitors of beta amyloid production

C - Chemistry, Metallurgy

07

D

C07D 333/34 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/4535 (2006.01) A61P 25/28 (2006.01) C07D 307/64 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2436526

Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.

L'invention concerne des composés représentés par la formule (I), dans laquelle R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, T, W, X, Y et Z sont tels que définis dans la description, ainsi que des sels, des hydrates et/ou des promédicaments pharmaceutiquement acceptables desdits composés. L'invention se rapporte en outre à des méthodes d'utilisation de ces composés pour inhiber la production de bêta-amyloïde et pour traiter la maladie d'Alzheimer et le syndrome de Down.

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