Heterocyclic topoisomerase poisons

Details Heterocyclic topoisomerase poisons Heterocyclic topoisomerase poisons

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/415 (2006.01) C07D 235/20 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2316221

The invention provides compounds of formula (I) wherein R1 to R5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, compositions, or salts to treat cancer.

Cette invention, qui a trait à des composés correspondant à la formule (I), formule dans laquelle R1, R2, R3, R4, et R5 ont l'une quelconque des valeurs définies dans le descriptif, concerne également des sels de ces composés, acceptables du point de vue pharmaceutique, des préparations pharmaceutiques renfermant ces composés ainsi que des méthodes d'utilisation de ces composés, de ces préparations ou de ces sels aux fins d'une thérapie anticancéreuse.

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