Heterocyclic topoisomerase poisons

Details Heterocyclic topoisomerase poisons Heterocyclic topoisomerase poisons

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/415 (2006.01) C07D 235/00 (2006.01) C07D 235/02 (2006.01) C07D 235/26 (2006.01) C07D 235/28 (2006.01) C07D 235/30 (2006.01) C07D 317/00 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2318347

The invention provides a topoisomerase poison of formula (I) wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a salt thereof, intermediates useful for preparing a compound of formula (I), and therapeutic methods comprising administering a compound of formula (I) or a salt thereof.

L'invention concerne un poison topoisomérase de la formule (I) dans laquelle R¿1?-R¿8? ont n'importe laquelle des significations définies dans la description, ou alors un sel de ce poison acceptable du point de vue pharmaceutique; l'invention concerne également des compositions pharmaceutiques comprenant un composé de la formule (I) ou un sel de ce composé, des intermédiaires utiles dans la préparation d'un composé de la formule (I) et des méthodes thérapeutiques comprenant l'administration d'un composé de la formule (I) ou d'un sel de ce composé.

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