Heterocyclically substituted amides used as calpain inhibitors

Details Heterocyclically substituted amides used as calpain inhibitors Heterocyclically substituted amides used as calpain inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/44 (2006.01) A61K 31/455 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 213/80 (2006.01) C07D 215/50 (2006.01) C07D 239/42 (2006.01) C07D 295/155 (2006.01) C07D 295/192 (2006.01) C07D 317/60 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2328440

The invention relates to heterocyclically substituted amides of the general formula (I), their tautomeric and isomeric forms, their enantiomeric and diastereomeric forms and to physiologically compatible salts thereof, where the variables have the meanings given in claim 1, which are suitable as enzyme inhibitors, especially of cysteine proteinases such as calpain and cathepsins.

L'invention concerne des amides substitués par voie hétérocyclique de la formule (I) et leurs formes tautomères et isomères, leurs formes énantiomères et diastéréomères ainsi que leurs sels physiologiquement compatibles. Les variables dont la signification est donnée dans la revendication 1, conviennent comme inhibiteurs d'enzymes, notamment de protéinases de cystéine telles que la calpaïne et la cathepsine.

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