Heterocyclicguanidines as 5ht- antagonists

Details Heterocyclicguanidines as 5ht- antagonists Heterocyclicguanidines as 5ht- antagonists

C - Chemistry, Metallurgy

07

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167/207, 260/302

C07D 261/08 (2006.01) A61K 31/395 (2006.01) C07D 277/28 (2006.01) C07D 277/30 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2016182

Heterocyclicguanidines at 5HT3 antagonists useful in the treatment of nausea, anxiety, pain, schizophrenia and gastrointestinal disorders. Image wherein said substituent is each methyl, methoxy, chloro, fluoro or bromo; Het is thiazolyl, furyl, thienyl or isox- azolyl; R1 is hydrogen or methyl; R2 and R3 when considered separately are each hydrogen, hydroxyethyl, alkyl having one to six carbon atoms, cycloalkyl having three to six carbon atoms or acetyl; and R2 and R3 when taken together are alkylene having two to three carbon atoms.

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