C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 233/64 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/00 (2006.01)
Patent
CA 2244837
A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by formula (V), wherein R3 is a radical selected from hydrido, alkyl, haloalkyl, aralkyl, heterocycloalkyl, heteroaralkyl, acyl, cyano, alkoxy, alkylthio, alkylthioalkyl, alkylsulfonyl, cycloalkylthio, cycloalkylthioalkyl, cycloalkylsulfonyl, cycloalkylsulfonylalkyl, haloalkylsulfonyl, arylsulfonyl, halo, hydroxyalkyl, alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclocarbonyl, cyanoalkyl, aminoalkyl, alkylaminoalkyl, N- arylaminoalkyl, N-alkyl-N-arylaminoalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, haloalkylcarbonyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, alkylaminocarbonylalkyl, heteroarylalkoxyalkyl, heteroaryloxyalkyl, heteroarylthioalkyl, aralkoxy, aralkylthio, heteroaralkoxy, heteroaralkylthio, heteroarylalkylthioalkyl, heteroaryloxy, heteroarylthio, arylthioalkyl, aryloxyalkyl, arylthio, aryloxy, aralkylthioalkyl, aralkoxyalkyl, aryl and heteroaryl; wherein R4 is a radical selected from hydrido, alkyl and halo; and wherein R13 and R14 are independently selected from aryl and heterocyclo, wherein R13 and R14 are optionally substituted at a substitutable position with one or more radicals independently selected from alkylsulfonyl, aminosulfonyl, halo, alkylthio, alkyl, cyano, carboxyl, alkoxycarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkoxy, amino, alkylamino, arylamino and nitro; provided at least one of R13 and R14 is aryl substituted with alkylsulfonyl or aminosulfonyl; or a pharmaceutically-acceptable salt thereof.
Cette invention concerne une classe de composés d'imidazolyle destinés à être utilisés pour traiter l'inflammation. Des composés particulièrement intéressants sont définis par la formule générale (V). Dans la formule R?3¿ représente un radical sélectionné entre hybrido, alkyle, haloalkyle, aralkyle, hétérocycloalkyle, hétéroaralkyle, acyl, cyano, alkoxy, alkylthio, alkylthioalkyle, alkylsulfonyle, cycloalkylthio, cycloalkylthioalkyle, cycloalkylsulfonyle, cycloalkylsulfonylalkyle, haloalkylsulfonyle, arylsulfonyle, halo, hydroxyalkyle, alcoxyalkyle, alkylcarbonyle, arylcarbonyle, aralkylcarbonyle, hétérocyclocarbonyle, cyanoalkyle, aminoalkyle, alkylaminoalkyle, N-arylaminoalkyle, N-alkyl-N-arylaminoalkyle, carboxyalkyle, alkoxycarbonylalkyle, alkoxycarbonyle, haloalkylcarbonyle, carboxyle, aminocarbonyle, alkylaminocarbonyle, alkylaminocarbonylalkyle, hétéroarylalkoxyalkyle, hétéroaryloxyalkyle, hétéroarylthioalkyle, aralcoxy, aralkylthio, hétéroaralcoxy, hétéroaralkylthio, hétéroarylalkylthioalkyle, hétéroaryloxy, hétéroarylthio, arylthioalkyle, aryloxyalkyle, arylthio, aryloxy, aralkylthioalkyle, aralcoxyalkyle, aryle et hétéroaryle; R?4¿ représente un radical sélectionné entre hybrido, alkyle et halo; R?13¿ and R?14¿ sont indépendamment sélectionnées entre aryle et hétérocyclo, R?13¿ et R?14¿ sont facultativement substitués à une position substituable à un ou plusieurs radicaux sélectionnés indépendamment entre alkylsulfonyle, aminosulfonyle, halo, alkylthio, alkyle, cyano, carboxyle, alkoxycarbonyle, haloalkyle, hydroxyle, alcoxy, hydroxyalkyle, alcoxyalkyle, haloalcoxy, amino, alkylamino, arylamino et nitro; à condition qu'au moins un des éléments R?13¿ et R?14¿ représente aryle remplacé par alkylsulfonyle ou aminosulfonyle ou bien un sel pharmaceutiquement acceptable de ces derniers.
Collins Paul W.
Huff Renee M.
Khanna Ish K.
Koszyk Francis J.
Partis Richard A.
G.d. Searle & Co.
Smart & Biggar
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