Heterocycly1-2-propyn-1-amines

Details Heterocycly1-2-propyn-1-amines Heterocycly1-2-propyn-1-amines

C - Chemistry, Metallurgy

07

D

167/242, 167/245

C07D 307/34 (2006.01) A61K 31/38 (2006.01) C07D 307/52 (2006.01) C07D 333/04 (2006.01) C07D 333/20 (2006.01)

Patent

CA 1309719

ABSTRACT This invention relates to novel heterocyclyl-2- propyn-1-amines of the formula Het-C ? C-CH2-NH2 wherein Het is 2- or 3-thienyl or 2- or 3-furyl, each Het ring optionally being substituted with from 1 to 3 moieties selected from the group consisting of lower alkyl of from one to about six carbon atoms, alkoxy of from 1 to about 6 carbon atoms, alkylthio of from 1 to about 6 carbon atoms, fluoro, bromo, chloro, carboxylic acid and hydroxymethyl and the pharmaceutically acceptable acid addition salts thereof, which are useful as dopamine beta hydroxylase inhibitors in the treatment of hypertension.

559481

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