Heterocyclyl derivatives of oxy-imino-substituted...

Details Heterocyclyl derivatives of oxy-imino-substituted... Heterocyclyl derivatives of oxy-imino-substituted...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/36 (2006.01) C07C 59/21 (2006.01) C07D 237/24 (2006.01) C07D 487/04 (2006.01)

Patent

CA 1148939

ABSTRACT OF THE DISCLOSURE The invention relates to heterocyclyl derivatives of oxyimino- substituted cephalosporins of formula Image I wherein R represents an amino, aminocarbonyl or carboxy group; R1 represents a hydrogen atom or an amino-protecting group chosen from formyl, chloroacetyl, dichloroacetyl, tert-butoxycarbonyl, p-nitrobenzyloxycarbonyl and trityl; and R2 represents a hydrogen atom, a hydroxy-protecting group chosen from formyl, acetyl, chloroacetyl, dichloroacetyl, trifluoroacetyl, tetrahydrofuranyl, trityl, trimethylsilyl and dimethyl-tert-butyl-silyl or a branched or straight chain C1 - C4 alkyl group. The compounds display high antibacterial activity in animals and humans not only against Gram-positive and Gram-negative bacteria normally susceptible to cephalosporins such as staphylococci, streptococci, diplococci, Klebisiella, Escherichia coli, Proteus mirabilis, Salmonella, Shigella, Haemophilus and Neisseria, but also against the strong beta-lactamase producer Gram-negative micro-organisms, such as, for example, Klebsiella aerogenes 1082 E, Escherichia coli Tem, Enterobacter cloacae P 99, indole- positive Proteus and the like, as well as against Pseudomonas aeruginosa strains, which are normally resistant to most cephalosporins.

351677

Affiliated with

Also associated with

Rating

Heterocyclyl derivatives of oxy-imino-substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclyl derivatives of oxy-imino-substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclyl derivatives of oxy-imino-substituted... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-724403