C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/79 (2006.01) A61K 31/34 (2006.01) A61P 3/00 (2006.01) C07C 311/02 (2006.01) C07D 307/91 (2006.01)
Patent
CA 2587566
Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
Composés et sels pharmaceutiquement acceptables de formule (A), qui sont utilisés dans le traitement de troubles métaboliques associés à la résistance à l'insuline, à la résistance à la leptine ou à l'hyperglycémie. Ces composés comprennent des inhibiteurs de protéine tyrosine phosphatases, plus particulièrement protéine tyrosine phasphatase-1B (PTP-1B) utilisés dans le traitement du diabète et d'autres maladies induites par PTP, notamment le cancer, les maladies neurodégénératives et analogues. Compositions pharmaceutiques comprenant des composés et méthodes de traitement des pathologies précitées utilisant de tels composés.
Fang Haiquan
Hu Shaojing
Van Zandt Michael C.
Whitehouse Darren
Osler Hoskin & Harcourt Llp
The Institutes For Pharmaceutical Discovery Llc
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