C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 241/00 (2006.01) C07D 277/00 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2573772
The present invention discloses compounds of formula (I) wherein m, n, p, R1, R2 and X, are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
La présente invention concerne des composés représentés par la formule I, dans laquelle m, n, p, R1, R2 et X, sont tels que définis dans la description, lesdits composés constituant de nouveaux antagonistes de l'hormone concentrant la mélanine (MCH), ainsi que des méthodes de préparation desdits composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant lesdits antagonistes de MCH ainsi que des méthodes d'utilisation desdites compositions afin de traiter l'obésité, les troubles métaboliques, les troubles digestifs tels que l'hyperphagie, ainsi que le diabète.
Mckittrick Brian
Qiang Li
Sasikumar Thavalakulamgara K.
Su Jing
Tang Haiqun
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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