Heterodimer of b-type transforming growth factors 2 and 3

Details Heterodimer of b-type transforming growth factors 2 and 3 Heterodimer of b-type transforming growth factors 2 and 3

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 1/36 (2006.01) C07K 14/495 (2006.01) C07K 16/22 (2006.01) C12N 15/18 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2096441

2096441 9208480 PCTABS00013 A new heterodimeric form of TGF-.beta. is described. This 25 KD molecule is active in an in vitro assay of inhibition of epithelial cell growth. The protein may be isolated from bone. When reduced, the protein elutes in two peaks by RP-HPLC. In immunoblots, the reduced protein from the earlier eluting peak reacts predominately with antibodies directed against TGF-.beta.3, while reduced protein from the later eluting peak reacts predominately with antibodies directed against TGF-.beta.2. The N-terminal amino acid sequence and immunoreactivity of the native protein are consistent with a heterodimer of TGF-.beta.2 and TGF-.beta.3.

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