Heterodimer polypeptide immunogen carrier composition and...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2372569

Polypeptide compositions comprising two distinct subunits which can form .alpha.- helical coiled-coil heterodimers are described. The two subunits can each have a different compound or bioactive moiety attached in a precisely-defined orientation and stoichiometry. In one embodiment of the invention, the polypeptide composition serves as a synthetic vaccine formulation having a B-cell antigen attached to one subunit, and a T-cell antigen attached to the other subunit.

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