Heterodimeric follicle stimulating hormone-fc (fsh-fc)...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) C07K 14/59 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2553187

The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (aFSH) linked directly or indirectly to a binding partner of neonatal Fc receptor (FcRn) and a second polypeptide including a beta subunit of FSH (.szlig.FSH) linked directly or indirectly to an FcRn binding partner. In one embodiment the FcRn binding partner includes an Fc fragment of an immunoglobulin, e.g., an Fc fragment of IgG. Also provided are methods making and using the fusion proteins of the invention. The invention provides a method for increasing fertility in a subject and a method for treating a subject having a disease state responsive to treatment by FSH.

L'invention porte sur de nouvelles protéines de fusion hétérodimères comprenant un premier polypeptide incluant une sous-unité alpha de FSH (.alpha.FSH) liée directement ou indirectement à un partenaire de liaison du récepteur néonatal Fc (FcRn) et un second polypeptide incluant une sous-unité bêta de FSH (.szlig.FSH) liée directement ou indirectement à un partenaire de liaison FcRn. Selon une forme d'exécution, le partenaire de liaison FcRn comprend un fragment Fc d'une immunoglobuline (un fragment Fc d'IgG). L'invention porte également sur des procédés de fabrication et d'utilisation des protéines de fusion précitées, ainsi que sur un procédé visant à accroître la fertilité chez un sujet et une méthode de traitement d'un sujet souffrant d'un état pathologique réagissant au traitement par FSH.

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