Heterodimeric four helix bundle cytokines

Details Heterodimeric four helix bundle cytokines Heterodimeric four helix bundle cytokines

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/20 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2614567

Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka IL-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.

L'invention concerne des protéines hétérodimériques comprenant deux cytokines à complexe hélicoïdal. Un des polypeptides comprend zsig81 et un second polypeptide comprenant soit p19 (aka IL-12A) soit p35 (aka IL-12A). Ces protéines peuvent être produites en tant que protéines hybrides ou exprimées en tant que chaîne unique. La protéine hétérodimérique comprenant zsig81 et p19 est nommée zcyto33f2 et la protéine hétérodimérique comprenant zsig81 et p35 et nommée zcyto35f2. Les protéines zcyto33f2 et zcyto35f2 sont associées à des types de cellules épithéliales notamment à l'épithélium des poumons et des intestins, et peuvent jouer un rôle dans des états physiologiques tels que l'inflammation.

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