C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2410551
The present invention relates to the production of bispecific or multispecific, bi- or tetravalent antibodies using recombinant DNA methods and recombinant production methods. The resulting antibody consists of one or two diabody molecules that are heterodimerized by creating a fusion protein with the CL and CH1 immunoglobulin constant domains.
La présente invention concerne la production d'anticorps bispécifiques ou multispécifiques, bi- ou tétravalents, par des techniques de recombinaison d'ADN et des techniques de production de recombinés. L'anticorps obtenu est constitué d'une ou de deux molécules de dianticorps qui subissent une hétérodimérisation via la création d'une protéine de fusion avec les domaines constants d'immunoglobuline CL et CH1.
Grooten Johan
Mertens Nico
Fetherstonhaugh & Co.
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (vib)
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