C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 1/16 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2106382
2106382 9315216 PCTABS00024 The present invention is based in part on the novel observation that two different types of nuclear receptors, retinoic acid receptors (RAR) and thyroid receptors (TR) dimerize with an RX receptor (RXR) to form a heterodimer which is capable of binding to retinoic acid response elements (RARE) or thyroid receptor response elements (TRE) at physiological conditions. Based on this observation, the present invention provides novel heterodimeric proteins, methods of identifying agents capable of binding the heterodimers of the present invention, methods of identifying DNA sequences capable of being bound by the heterodimers and methods to identify RA metabolic enzymes and proteins which are required for the activation function of nuclear receptors.
Chambon Pierre
Kastner Philippe
Leid Mark
Centre National de La Recherche Scientifique
E.r. Squibb & Sons Inc.
Gowling Lafleur Henderson Llp
Institut National de La Sante Et de La Recherche Medicale
University Louis Pasteur
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