Heterodimeric protein binding compositions

Details Heterodimeric protein binding compositions Heterodimeric protein binding compositions

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2599265

The invention relates to methods for making modified immunoglobulin compositions to maximize antigen binding and effector function by swapping of sequences of the heavy and light chains within an IgG Fab domain for the purpose of reorienting the Fc domain relative to the antigen-binding domain.

La présente invention a trait à des procédés pour la fabrication de compositions à base d'immunoglobulines modifiées en vue de maximiser la liaison à l'antigène et la fonction effectrice de séquences des chaînes lourdes et légères dans un domaine Fab d'IgG en vue de l'orientation du domaine Fc par rapport au domaine de liaison à l'antigène.

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