Heterogenous and homogeneous mouse variants lacking sno gene

A - Human Necessities – 01 – K

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Details

A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2367067

Functions of sno gene are analyzed by constructing heterogenous or homogeneous mouse variants lacking sno gene to thereby provide heterogenous or homogeneous mouse variants lacking sno gene, cells of these animals and screening systems with the use of these animals or cells. Non-human animals, preferably mice, lacking sno gene and cells thereof. The above animals or cells thereof include both of heterogenous variants and homogeneous variants. A method for screening candidates for drugs by using the above animals or cells thereof.

Les fonctions du gène sno sont analysées par construction de variants de souris hétérogènes ou homogènes dépourvus du gène sno afin d'obtenir ainsi des variants de souris hétérogènes ou homogènes dépourvues du gène sno, des cellules de ces animaux et des systèmes de criblage à l'aide de ces animaux ou cellules. L'invention a trait à des animaux, de préférence des souris, dépourvus du gène sno et leurs cellules. Les animaux précités ou leurs cellules contiennent à la fois des variants hétérogènes et des variants homogènes. L'invention a également trait à une méthode de criblage de candidats pour l'obtention de médicaments à l'aide des animaux précités ou de leurs cellules.

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