Heteropolycyclic compounds and their use as metabotropic...

Details Heteropolycyclic compounds and their use as metabotropic... Heteropolycyclic compounds and their use as metabotropic...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/4725 (2006.01) A61K 31/497 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2381975

Compound of formula (II) wherein X, Y, and Z are independently selected from the group consisting of N, O, S, C, and CO wherein at least one of X, Y, and Z is a heteroatom; Ar1 and Ar2 are independently selected from the group consisting of a heterocyclic or fused heterocyclic moiety and an aromatic moiety; act as antagonist at metabotropic glutamate receptors, and are useful for treating neurological diseases and disorders.

L'invention concerne un composé correspondant à la formule (II), dans laquelle X, Y et Z sont choisis de manière indépendante dans le groupe constitué par N, O, S, C et CO, l'un au moins parmi X, Y et Z représentant un hétéroatome; Ar?1¿ et Ar?2¿ sont choisis de manière indépendante dans le groupe constitué par une fraction hétérocyclique, une fraction hétérocyclique condensée, et une fraction aromatique. Ce composé agit en tant qu'antagoniste des récepteurs du glutamate métabotrope et ils sont utiles pour traiter des maladies et pathologies d'ordre neurologique.

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