C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/429 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2748843
The present invention relates to novel compounds of Formula (I), wherein wherein X1, X2, Y, Z1, Z2, Z3, m and (A)m are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mG1uR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mG1uR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mG1uR4 is involved.
La présente invention concerne de nouveaux composés de Formule (I), où X1, X2, Y, Z1, Z2, Z3, M et (A)m sont tels que définis dans la Formule (I); les composés selon l'invention sont des modulateurs des récepteurs glutamatergiques métabotropes de sous-type 4 (« mGluR4 ») qui peuvent être employés dans le traitement prophylactique ou thérapeutique des troubles du système nerveux central ainsi que d'autres troubles faisant intervenir les récepteurs mGluR4. La présente invention concerne également des compositions pharmaceutiques et l'emploi de tels composés dans la fabrication de médicaments, ainsi que l'emploi de tels composés dans le traitement prophylactique et thérapeutique des pathologies impliquant mGluR4.
Bolea Christelle
Celanire Sylvain
Addex Pharma S.a.
Smart & Biggar
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